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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
9.09
Human Site:
S1056
Identified Species:
12.5
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S1056
D
N
P
I
E
E
I
S
V
L
S
P
E
D
L
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S1056
D
N
P
I
E
E
I
S
V
L
S
P
E
D
L
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S1055
D
N
P
I
E
E
I
S
V
L
S
P
E
D
L
Dog
Lupus familis
XP_535848
1288
147094
A1056
N
N
P
L
E
E
I
A
V
L
S
P
E
D
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
A1054
D
N
P
V
E
T
V
A
V
L
S
Q
E
E
L
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
L990
Y
G
D
L
C
E
D
L
K
D
A
Q
A
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
N847
K
D
P
G
S
I
T
N
Q
I
A
L
L
E
A
Chicken
Gallus gallus
NP_989849
1274
145838
P1027
D
K
P
P
E
E
L
P
V
L
S
Q
E
E
L
Frog
Xenopus laevis
P50532
1290
146971
P1050
D
I
P
E
E
V
L
P
G
L
A
Q
E
E
L
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
P1055
G
V
P
A
E
E
L
P
A
L
N
P
D
Q
L
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
P1051
D
N
P
A
E
E
L
P
V
L
T
P
A
E
L
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
N1416
E
S
Q
K
K
S
H
N
E
I
Q
D
K
L
E
Honey Bee
Apis mellifera
XP_396862
1282
148175
E976
L
I
E
L
K
E
E
E
L
N
E
L
D
E
N
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
N1147
L
L
S
D
E
K
I
N
E
I
S
S
R
D
A
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
P1054
R
E
N
P
E
T
L
P
E
Y
M
P
E
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
D998
H
M
E
Q
I
Q
K
D
L
V
D
P
D
K
L
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
D1131
H
T
L
G
M
L
D
D
N
K
M
D
S
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
80
N.A.
60
6.6
N.A.
6.6
60
40
40
60
0
6.6
26.6
33.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
26.6
N.A.
40
73.3
60
60
80
40
40
46.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
0
0
0
12
6
0
18
0
12
0
12
% A
% Cys:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
42
6
6
6
0
0
12
12
0
6
6
12
18
36
0
% D
% Glu:
6
6
12
6
65
53
6
6
18
0
6
0
48
42
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
6
6
0
12
0
0
0
0
6
0
0
0
0
0
0
% G
% His:
12
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% H
% Ile:
0
12
0
18
6
6
30
0
0
18
0
0
0
0
0
% I
% Lys:
6
6
0
6
12
6
6
0
6
6
0
0
6
6
6
% K
% Leu:
12
6
6
18
0
6
30
6
12
53
0
12
6
6
65
% L
% Met:
0
6
0
0
6
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
6
36
6
0
0
0
0
18
6
6
6
0
0
0
6
% N
% Pro:
0
0
59
12
0
0
0
30
0
0
0
48
0
0
0
% P
% Gln:
0
0
6
6
0
6
0
0
6
0
6
24
0
6
0
% Q
% Arg:
6
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% R
% Ser:
0
6
6
0
6
6
0
18
0
0
42
6
6
0
0
% S
% Thr:
0
6
0
0
0
12
6
0
0
0
6
0
0
0
0
% T
% Val:
0
6
0
6
0
6
6
0
42
6
0
0
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _